Huang Xiao-Chun, Zhao Di, Guo Yue-Wei, Wu Hou-Ming, Lin Li-Ping, Wang Zhong-Hua, Ding Jian, Lin Yong-Shui
State key laboratory of Drug Research, Institute of Materia Medica, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Zu Chong Zhi Road 555, Zhangjiang High-Tech Park, Shanghai 201203, China.
Bioorg Med Chem Lett. 2004 Jun 21;14(12):3117-20. doi: 10.1016/j.bmcl.2004.04.029.
A novel polyhydroxy compound with a linear carbon-chain, lingshuiol (1), had been isolated from the cultured marine dinoflagellate Amphidinium sp. Its structure was elucidated by extensive analysis of 2D NMR spectral data. Lingshuiol possessed a powerful cytotoxic activity against A-549 and HL-60 cells in vitro with the IC(50) of 0.21 and 0.23 microM, respectively.
一种具有直链碳链的新型多羟基化合物——陵水藻醇（1），已从培养的海洋甲藻 Amphidinium sp. 中分离出来。通过对二维核磁共振光谱数据的广泛分析阐明了其结构。陵水藻醇在体外对 A-549 和 HL-60 细胞具有强大的细胞毒性活性，IC(50) 分别为 0.21 和 0.23 微摩尔。
