N-acetyl-beta-D-glucosaminidase activity in urine of dental personnel.
作者信息
Tassi C, Mancuso F, Lomurno G, Lotito M, Feligioni L, De Bellis F, Eramo S, Capodicasa E
机构信息
Dipartimento di Scienze Biochimiche e Biotecnologie Molecolari, Sezione di Medicina di Laboratorio, Università degli Studi di Perugia, Perugia, Italy.
出版信息
Clin Chim Acta. 2004 Jun;344(1-2):211-3. doi: 10.1016/j.cccn.2004.02.028.
BACKGROUND
Dental personnel is exposed to several potential nephrotoxic agents. Urinary N-acetyl-beta-d-glucosaminidase (U-NAG) activity has emerged as a sensitive marker of early nephrotoxicity.
METHODS
U-NAG was evaluated, by fluorimetric assay, in urine from 30 healthy subjects and 30 dental personnels.
RESULTS
The median value of U-NAG activity (133.5 U/mmol urinary creatinine (U-Cr) in urines of dental personnel was not statistically different (P>0.05) from activity (100.7 U/mmol U-Cr) of control urines.
CONCLUSIONS
The results suggest that, for dental personnel, exposure to potential nephrotoxic agents is not usually high enough to increase U-NAG activity.
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