[尿N-乙酰-β-D-氨基葡萄糖苷酶在急性百草枯中毒患者肾损伤中的意义]
[The significance of urine N-acetyl-beta-D-glucosaminidase in kidney injury with patients acute paraquat poisoning].
作者信息
Shi Xu-bin, He Jun-ling, Lu Yuang-qiang
机构信息
Huzhou Central Blood Station, Huzhou ZhejiangProvince, China.
出版信息
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2013 Mar;31(3):223-4.
OBJECTIVES
To test the hypothesis that urine N-acetyl-beta-D-glucosaminidase (NAG) is a nearly biomarker for acute kidney injury in patients with acute paraquat poisoning.
METHODS
Forty-four patients with paraquat intoxication and 40 age and gender-matched healthy control participants were recruited. The urine N-acetyl-beta-D-glucosaminidase was determined by spectrophotometric methods.
RESULTS
The urine N-acetyl-beta-D-glucosaminidase activities in the patients with paraquat poisoning were higher than the corresponding values in the control participants (P<0.01); The prevalence rate of mortality was significantly higher in subjects with N-acetyl-beta-D-glucosaminidase activities ≥25 U/g Cr than in those N-acetyl-beta-D-glucosaminidase activities <25 Ulg Cr (34.4% vs 16.7%, P<0.01).
CONCLUSIONS
The urine N-acetyl-beta-D-glucosaminidase could be used as an early biomarker for acute kidney injury and predictor of mortality inpatients with acute paraquat intoxication.
目的
验证尿N-乙酰-β-D-氨基葡萄糖苷酶（NAG）是急性百草枯中毒患者急性肾损伤的一种近乎理想的生物标志物这一假设。
方法
招募了44例百草枯中毒患者以及40名年龄和性别匹配的健康对照者。采用分光光度法测定尿N-乙酰-β-D-氨基葡萄糖苷酶。
结果
百草枯中毒患者的尿N-乙酰-β-D-氨基葡萄糖苷酶活性高于对照者的相应值（P<0.01）；N-乙酰-β-D-氨基葡萄糖苷酶活性≥25 U/g Cr的患者死亡率显著高于N-乙酰-β-D-氨基葡萄糖苷酶活性<25 U/g Cr的患者（34.4% 对16.7%，P<0.01）。
结论
尿N-乙酰-β-D-氨基葡萄糖苷酶可作为急性百草枯中毒患者急性肾损伤的早期生物标志物及死亡率的预测指标。
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