González Gloria M, Tijerina Rolando, Najvar Laura K, Bocanegra Rosie, Rinaldi Michael G, Graybill John R
Department of Medicine, Division of Infectious Diseases, University of Texas Health Science Center at San Antonio, 78229-3900, USA.
Antimicrob Agents Chemother. 2004 Jun;48(6):2140-3. doi: 10.1128/AAC.48.6.2140-2143.2004.
The therapeutic efficacy of three lipid formulations of amphotericin B was compared with that of conventional amphotericin B in treatment of murine coccidioidomycosis. All treatments prolonged survival compared with the no-treatment group (P < 0.0001). Although conventional amphotericin B was more active than lipid formulations on reducing quantitative fungal load on a milligram-per-kilogram basis (P < 0.003 to 0.0002), the lipid preparations could be administered at higher doses, sterilizing liver and spleen tissues. The efficacies of the lipid preparations were similar in this murine model of coccidioidomycosis.
将两性霉素B的三种脂质制剂的治疗效果与传统两性霉素B在治疗小鼠球孢子菌病中的效果进行了比较。与未治疗组相比,所有治疗均延长了生存期(P < 0.0001)。尽管传统两性霉素B在以毫克每千克为基础降低定量真菌负荷方面比脂质制剂更具活性(P < 0.003至0.0002),但脂质制剂可以更高剂量给药,从而使肝脏和脾脏组织灭菌。在这个小鼠球孢子菌病模型中,脂质制剂的疗效相似。