信号素：生长锥排斥性导向的介导因子

Semaphorins: mediators of repulsive growth cone guidance.

作者信息

Kolodkin A L

机构信息

Dept of Neuroscience, The Johns Hopkins University School of Medicine, 725 N. Wolfe St, Baltimore, MD 21205, USA.

出版信息

Trends Cell Biol. 1996 Jan;6(1):15-22. doi: 10.1016/0962-8924(96)81033-6.

DOI:10.1016/0962-8924(96)81033-6

PMID:15157527

Abstract

During development, neuronal growth cones encounter a variety of guidance cues while mediating axon path finding, target recognition and synapse formation. It is clear that repulsive guidance mechanisms play an essential role in these processes. The semaphorin gene family, which is conserved from invertebrates to mammals, includes members that mediate repulsive guidance. Molecular and cellular analysis of this gene family is providing insight into how inhibitory cues function during neurodevelopment.

摘要

在发育过程中，神经元生长锥在介导轴突路径寻找、靶标识别和突触形成时会遇到多种导向线索。很明显，排斥性导向机制在这些过程中起着至关重要的作用。从无脊椎动物到哺乳动物都保守的信号素基因家族，包含介导排斥性导向的成员。对该基因家族的分子和细胞分析正在为深入了解抑制性线索在神经发育过程中的作用机制提供帮助。