Abu Jhaisha Samira, Hohlstein Philipp, Yagmur Eray, Köller Vera, Pollmanns Maike R, Adams Jule K, Wirtz Theresa H, Brozat Jonathan F, Bündgens Lukas, Hamesch Karim, Weiskirchen Ralf, Tacke Frank, Trautwein Christian, Koch Alexander
Department of Medicine III, RWTH-University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany.
Institute of Laboratory Medicine, Western Palatinate Hospital, 67655 Kaiserslautern, Germany.
Diagnostics (Basel). 2024 Feb 8;14(4):370. doi: 10.3390/diagnostics14040370.
Semaphorin 4D (Sema4D), also known as CD100, is a multifunctional transmembrane protein with immunoregulatory functions. Upon the activation of immune cells, soluble Semaphorin 4D (sSema4D) is proteolytically cleaved from the membrane by metalloproteinases. sSema4D levels are elevated in various (auto-)inflammatory diseases. Our aim was to investigate sSema4D levels in association with sepsis and critical illnesses and to evaluate sSema4D's potential as a prognostic biomarker. We measured sSema4D levels in 192 patients upon admission to our medical intensive care unit. We found similar levels of sSema4D in 125 patients with sepsis compared to 67 non-septic patients. sSema4D levels correlated with leukocytes but not with other markers of systemic inflammation such as C-reactive protein or procalcitonin. Most interestingly, in a subgroup of patients suffering from pre-existing liver cirrhosis, we observed significantly higher levels of sSema4D. Consistently, sSema4D was also positively correlated with markers of hepatic and cholestatic injury. Our study suggests that sSema4D is not regulated in sepsis compared to other causes of critical illness. However, sSema4D seems to be associated with hepatic injury and inflammation.
信号素4D（Sema4D），也称为CD100，是一种具有免疫调节功能的多功能跨膜蛋白。免疫细胞激活后，可溶性信号素4D（sSema4D）会被金属蛋白酶从细胞膜上蛋白水解切割下来。在各种（自身）炎症性疾病中，sSema4D水平会升高。我们的目的是研究与脓毒症和危重病相关的sSema4D水平，并评估sSema4D作为预后生物标志物的潜力。我们在192例患者入住我们的医学重症监护病房时测量了sSema4D水平。我们发现，125例脓毒症患者的sSema4D水平与67例非脓毒症患者相似。sSema4D水平与白细胞相关，但与其他全身炎症标志物如C反应蛋白或降钙素原无关。最有趣的是，在一组患有肝硬化的患者亚组中，我们观察到sSema4D水平显著更高。同样，sSema4D也与肝损伤和胆汁淤积损伤标志物呈正相关。我们的研究表明，与其他危重病原因相比，脓毒症中sSema4D不受调控。然而，sSema4D似乎与肝损伤和炎症有关。
