Cracowski J-L
Laboratoire de pharmacologie, HP2, faculté de médecine de Grenoble, domaine de la Merci, 38700 La Tronche, France.
Rev Med Interne. 2004 Jun;25(6):459-63. doi: 10.1016/j.revmed.2004.02.022.
Isoprostanes are arachidonic acid metabolites produced by a free-radical-dependent mechanism.
The 15-series F2-isoprostanes and some 15-series E2-isoprostanes mediate vasoconstriction in different vascular beds and species. Furthermore, 15-F2t-IsoP induces smooth muscle cells mitogenesis and monocyte adhesion to endothelial cells. In clinical studies, 15-F2t-IsoP levels are increased in vascular disorders involving atherosclerosis, ischemia-reperfusion and inflammation.
Whether the effects observed in vitro are observed consistently in vivo at physiological concentrations and whether these effects contribute to pathological states in vivo is still debated.
