Cracowski Jean-Luc
Laboratoire de Pharmacologie, Faculté de Médecine de Grenoble, Domaine de la Merci, La Tronche 38700, France.
Chem Phys Lipids. 2004 Mar;128(1-2):75-83. doi: 10.1016/j.chemphyslip.2003.10.006.
Among the isoprostanes, the 15-series F2-isoprostanes and 15-E2t-IsoP mediate vasoconstriction in different vascular beds and species. In addition, 15-F2t-IsoP induces smooth muscle cells mitogenesis and monocyte adhesion to endothelial cells. In clinical studies, 15-F2t-IsoP levels are increased in some vascular disorders involving atherosclerosis, ischemia-reperfusion and inflammation. Whether the same effects observed in vitro are observed consistently in vivo at physiological concentrations and whether these effects contribute to pathological states in vivo is still debated.
在异前列腺素中，15-系列F2-异前列腺素和15-E2t-异前列腺素在不同的血管床和物种中介导血管收缩。此外，15-F2t-异前列腺素可诱导平滑肌细胞有丝分裂以及单核细胞与内皮细胞的黏附。在临床研究中，在一些涉及动脉粥样硬化、缺血再灌注和炎症的血管疾病中，15-F2t-异前列腺素水平会升高。在生理浓度下，体外观察到的相同效应在体内是否能持续观察到，以及这些效应是否会导致体内病理状态，目前仍存在争议。
