Peroxisome proliferators and peroxisome proliferator-activated receptor alpha: biotic and xenobiotic sensing.
作者信息
Reddy Janardan K
机构信息
Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, Illinois 60611, USA.
出版信息
Am J Pathol. 2004 Jun;164(6):2305-21. doi: 10.1016/s0002-9440(10)63787-x.
Abstract
摘要
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Protein profiling of mouse livers with peroxisome proliferator-activated receptor alpha activation.过氧化物酶体增殖物激活受体α激活的小鼠肝脏蛋白质谱分析。
Mol Cell Biol. 2004 Jul;24(14):6288-97. doi: 10.1128/MCB.24.14.6288-6297.2004.
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Transcription coactivator PBP, the peroxisome proliferator-activated receptor (PPAR)-binding protein, is required for PPARalpha-regulated gene expression in liver.转录共激活因子PBP，即过氧化物酶体增殖物激活受体（PPAR）结合蛋白，是肝脏中PPARα调节基因表达所必需的。
J Biol Chem. 2004 Jun 4;279(23):24427-34. doi: 10.1074/jbc.M402391200. Epub 2004 Mar 29.
3
Expression of base excision DNA repair genes is a sensitive biomarker for in vivo detection of chemical-induced chronic oxidative stress: identification of the molecular source of radicals responsible for DNA damage by peroxisome proliferators.碱基切除DNA修复基因的表达是体内检测化学诱导慢性氧化应激的敏感生物标志物：确定过氧化物酶体增殖物导致DNA损伤的自由基分子来源。
Cancer Res. 2004 Feb 1;64(3):1050-7. doi: 10.1158/0008-5472.can-03-3027.
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Peroxisome proliferator-activated receptors, fatty acid oxidation, steatohepatitis and hepatocarcinogenesis.过氧化物酶体增殖物激活受体、脂肪酸氧化、脂肪性肝炎与肝癌发生
Curr Mol Med. 2003 Sep;3(6):561-72. doi: 10.2174/1566524033479537.
5
The thyroid hormone receptor-associated protein TRAP220 is required at distinct embryonic stages in placental, cardiac, and hepatic development.甲状腺激素受体相关蛋白TRAP220在胎盘、心脏和肝脏发育的不同胚胎阶段是必需的。
Mol Endocrinol. 2003 Dec;17(12):2418-35. doi: 10.1210/me.2003-0097. Epub 2003 Sep 18.
6
Overexpression of peroxisome proliferator-activated receptor-alpha (PPARalpha)-regulated genes in liver in the absence of peroxisome proliferation in mice deficient in both L- and D-forms of enoyl-CoA hydratase/dehydrogenase enzymes of peroxisomal beta-oxidation system.在缺乏过氧化物酶体β-氧化系统的L型和D型烯酰辅酶A水合酶/脱氢酶的小鼠中，过氧化物酶体增殖物激活受体α（PPARα）调控的基因在肝脏中过表达，且不存在过氧化物酶体增殖。
J Biol Chem. 2003 Nov 21;278(47):47232-9. doi: 10.1074/jbc.M306363200. Epub 2003 Sep 18.
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Microbodies and the problem of mitochondrial regeneration in liver cells.微体与肝细胞中线粒体再生的问题。
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