Suzuki Noriko, Saunders Brian P, Thomas-Gibson Siwan, Akle Charles, Marshall Michele, Halligan Steve
Wolfson Unit for Endoscopy, St. Mark's Hospital, Harrow, Middlesex, United Kingdom.
Dis Colon Rectum. 2004 Jul;47(7):1201-7. doi: 10.1007/s10350-004-0556-5. Epub 2004 Jun 3.
Self-expanding metal stents are now an established treatment for malignant colonic obstruction. Favorable outcomes have been reported both for cancer palliation and treatment of acute obstruction as a "bridge" to surgery. However, little data exists regarding the use of stents for benign colonic obstruction.
All cases of colonic stent insertion occurring between December 1996 to October 2002 were reviewed. During the study period, 36 patients with malignant obstruction and 6 patients with benign obstructive disease underwent placement of self-expandable stents using a combined endoscopic and fluoroscopic technique.
Stent placement was successful in 36 of 42 patients (86 percent). Complications occurred in 16 of 36 patients (44 percent): migration (n = 7), reobstruction (n = 5), perforation (n = 2), fistula formation (n = 1), and stent fracture (n = 1). Stent placement was successful in 100 percent of patients with benign strictures but poststent migration was frequent (2/6).
Stent insertion provided an effective outcome in patients with malignant colonic obstruction as a palliative and preoperative therapy. Although a relatively high migration rate was observed in patients with benign strictures, stenting was still effective in providing luminal patency (median follow-up, 7.5 months). Stenting should be considered as a first-line treatment for malignant strictures and as a potential therapy for selected benign strictures.
自膨式金属支架现已成为治疗恶性结肠梗阻的既定疗法。已有关于其用于癌症姑息治疗以及作为手术“桥梁”治疗急性梗阻的良好疗效报道。然而,关于使用支架治疗良性结肠梗阻的数据却很少。
回顾了1996年12月至2002年10月期间所有结肠支架置入病例。在研究期间,36例恶性梗阻患者和6例良性梗阻性疾病患者采用内镜与荧光镜联合技术置入了自膨式支架。
42例患者中有36例(86%)支架置入成功。36例患者中有16例(44%)发生并发症:移位(n = 7)、再梗阻(n = 5)、穿孔(n = 2)、瘘管形成(n = 1)以及支架断裂(n = 1)。良性狭窄患者支架置入成功率为100%,但支架置入后移位频繁(2/6)。
支架置入对于恶性结肠梗阻患者作为姑息治疗和术前治疗可取得有效疗效。尽管良性狭窄患者中观察到相对较高的移位率,但支架置入在提供管腔通畅方面仍然有效(中位随访时间,7.5个月)。支架置入应被视为恶性狭窄的一线治疗方法以及部分选定良性狭窄的潜在治疗方法。