黑曲霉将10-脱氧青蒿素羟基化为15-羟基-10-脱氧青蒿素。
Hydroxylation of 10-deoxoartemisinin to 15-hydroxy-10-deoxoartemisinin by Aspergillus niger.
作者信息
Parshikov Igor A, Miriyala Bruhaspathy, Avery Mitchell A, Williamson John S
机构信息
Department of Medicinal Chemistry, School of Pharmacy, University of Mississippi, University, MS 38677-1848, USA.
出版信息
Biotechnol Lett. 2004 Apr;26(7):607-10. doi: 10.1023/b:bile.0000021965.55420.e9.
Abstract
The microbial hydroxylation of 10-deoxoartemisinin was investigated with the aim of obtaining preparative yields of hydroxy derivatives. During 14 d at 28 degrees C and pH 6.5 Aspergillus niger transformed 10-deoxoartemisinin (500 mg l(-1)) to 15-hydroxy-10-deoxoartemisinin (26%) and 7beta-hydroxy-10-deoxoartemisinin (69%).
摘要
为了获得羟基衍生物的制备产率，对10-脱氧青蒿素的微生物羟基化反应进行了研究。在28℃和pH 6.5的条件下，黑曲霉在14天内将10-脱氧青蒿素（500 mg l(-1)）转化为15-羟基-10-脱氧青蒿素（26%）和7β-羟基-10-脱氧青蒿素（69%）。
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