多孢毛霉和黑曲霉对青蒿素的微生物代谢
Microbial metabolism of artemisinin by Mucor polymorphosporus and Aspergillus niger.
作者信息
Zhan Ji-Xun, Zhang Yuan-Xing, Guo Hong-Zhu, Han Jian, Ning Li-Li, Guo De-An
机构信息
The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, People's Republic of China.
出版信息
J Nat Prod. 2002 Nov;65(11):1693-5. doi: 10.1021/np020113r.
PMID:12444705
Abstract
Artemisinin (1) was transformed by Mucor polymorphosporus and Aspergillus niger. Five products were identified as 9beta-hydroxyartemisinin (2), 3beta-hydroxyartemisinin (3), deoxyartemisinin (4), 3beta-hydroxydeoxyartemisinin (5), and 1alpha-hydroxydeoxyartemisinin (6). Products 2, 3, and 6 are new compounds.
摘要
青蒿素（1）被多孢毛霉和黑曲霉转化。鉴定出了5种产物，分别为9β-羟基青蒿素（2）、3β-羟基青蒿素（3）、脱氧青蒿素（4）、3β-羟基脱氧青蒿素（5）和1α-羟基脱氧青蒿素（6）。产物2、3和6是新化合物。
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