Hasan M Y, Kosanovic M, Fahim M A, Adem A, Petroianu G
Department of Pharmacology, Faculty of Medicine, United Arab Emirates University, PO Box 17666, Al Ain, United Arab Emirates.
Vet Hum Toxicol. 2004 Jun;46(3):119-21.
Pollution has increased with industrialization and humans are subjected to exposure to heavy metals from different environmental sources. In oil-producing countries heavy metals are considered a major threat to the population. Metals such as lead, aluminum, manganese, nickel and cadmium may impact various organs of the body, and controlling their toxicity is crucial for individuals at risk. Previous studies utilized blood levels for monitoring metal toxicity. The current study was designed to investigate exposure to lead, aluminum, manganese, nickel and cadmium using scalp hair. Hair samples were randomly collected from 42 children (aged 6-18 y) representing rural and urban areas of the United Arab Emirates. The rural regions were defined as at least 50 km away from factories or traffic sites. Immediately after cutting, hairs were stored in plastic bags and attached to a questionnaire with the relevant background information. Samples were dried, weighed and sealed with polyethylene envelopes. Following extraction procedures with nitric acid, ICP-MS was utilized for metals determination. The analytical instrument showed a high degree of sensitivity and revealed significant differences between levels of some metals in hairs from rural and urban areas. Children from rural areas had mean hair lead levels (microg/g) of 0.79 + 0.10 whereas children from urban area had higher hair lead levels (3.47 + 0.47). Measuring metals concentration in scalp hair could be a useful method for studying exposure and assessing environmental pollution. Although the technique has the potential of being an effective tool for evaluating extent of pollution and identifying potentially toxic elements, it cannot yet replace the standard procedures of measuring air, water and soil metal content.
随着工业化进程,污染日益加剧,人类暴露于来自不同环境源的重金属之中。在产油国,重金属被视为对民众的一大威胁。铅、铝、锰、镍和镉等金属可能会影响人体的各个器官,控制这些金属的毒性对于处于风险中的个体至关重要。以往的研究利用血液水平来监测金属毒性。本研究旨在通过头皮毛发来调查铅、铝、锰、镍和镉的暴露情况。从代表阿拉伯联合酋长国农村和城市地区的42名儿童(6 - 18岁)中随机采集毛发样本。农村地区定义为距离工厂或交通站点至少50公里。毛发剪下后立即存放在塑料袋中,并附上包含相关背景信息的问卷。样本经干燥、称重后用聚乙烯信封密封。经过硝酸提取程序后,使用电感耦合等离子体质谱法(ICP - MS)测定金属含量。该分析仪器具有高度敏感性,揭示了农村和城市地区毛发中某些金属含量存在显著差异。农村地区儿童的毛发铅平均水平(微克/克)为0.79 ± 0.10,而城市地区儿童的毛发铅水平更高(3.47 ± 0.47)。测量头皮毛发中的金属浓度可能是研究暴露情况和评估环境污染的一种有用方法。尽管该技术有潜力成为评估污染程度和识别潜在有毒元素的有效工具,但它尚不能取代测量空气、水和土壤中金属含量的标准程序。