Rubenstein C S, Pigott T A, L'Heureux F, Hill J L, Murphy D L
Section on Clinical Neuropharmacology, National Institute of Mental Health, Bethesda, MD 20892.
J Clin Psychiatry. 1992 Sep;53(9):309-14.
Obsessive compulsive disorder (OCD) is currently classified as an anxiety disorder although it possesses many characteristics that distinguish it from other anxiety disorders. Clinically and neurobiologically, OCD appears to overlap somewhat with the eating disorders.
To assess in a controlled fashion the lifetime prevalence of the eating disorders in patients with OCD, we administered portions of the Structured Clinical Interview for DSM-III-R, Patient Version (SCID-P), to 62 patients (31 men, 31 women) with a primary DSM-III-R diagnosis of OCD.
Among the OCD patients, the lifetime prevalence of anorexia nervosa and/or bulimia nervosa was 12.9% (N = 8), and an additional 17.7% (N = 11) met subthreshold criteria for either anorexia or bulimia nervosa. Interestingly, unlike multiple epidemiologic studies that have reported a substantial female preponderance among patients diagnosed with anorexia or bulimia nervosa, there was no significant gender difference in the lifetime prevalence of eating disorders among the patients with OCD. Almost 13% (N = 4) of the men and 6.5% (N = 2) of the women with OCD met criteria for a lifetime diagnosis of anorexia nervosa and 3.2% (N = 1) of the men and 6.5% (N = 2) of the women with OCD met criteria at some time in their lives for bulimia nervosa. In addition, subthreshold criteria for anorexia nervosa or bulimia nervosa were met by an additional 12.9% (N = 4) of the men and 22.6% (N = 7) of the women.
These data suggest that OCD patients, regardless of gender, have a substantial lifetime prevalence of anorexia and/or bulimia nervosa.
尽管强迫症(OCD)具有许多使其有别于其他焦虑症的特征,但目前它被归类为一种焦虑症。在临床和神经生物学方面,强迫症似乎与饮食失调症有一定程度的重叠。
为了以可控方式评估强迫症患者中饮食失调症的终生患病率,我们对62名原发性DSM-III-R诊断为强迫症的患者(31名男性,31名女性)进行了《精神疾病诊断与统计手册第三版修订版》(DSM-III-R)结构性临床访谈患者版(SCID-P)的部分内容评估。
在强迫症患者中,神经性厌食症和/或神经性贪食症的终生患病率为12.9%(N = 8),另有17.7%(N = 11)符合神经性厌食症或神经性贪食症的阈下标准。有趣的是,与多项流行病学研究报告的被诊断为神经性厌食症或神经性贪食症的患者中女性占绝大多数不同,强迫症患者中饮食失调症的终生患病率在性别上没有显著差异。几乎13%(N = 4)的男性和6.5%(N = 2)的女性强迫症患者符合神经性厌食症终生诊断标准,3.2%(N = 1)的男性和6.5%(N = 2)的女性强迫症患者在其生命中的某个时候符合神经性贪食症标准。此外,另有12.9%(N = 4)的男性和22.6%(N = 7)的女性符合神经性厌食症或神经性贪食症的阈下标准。
这些数据表明,无论性别如何,强迫症患者中神经性厌食症和/或神经性贪食症的终生患病率都相当高。