Fuss Martin, Salter Bill J, Cheek Dennis, Sadeghi Amir, Hevezi James M, Herman Terence S
Department of Radiation Oncology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA.
Radiother Oncol. 2004 Jun;71(3):339-45. doi: 10.1016/j.radonc.2004.03.003.
To evaluate the repositioning accuracy of a commercially available thermoplastic mask system for single dose radiosurgery treatments and fractionated treatment courses.
The repositioning accuracy of the Raycast-HP mask system (Orfit Industries, Wijnegem, Belgium) was analyzed. Twenty-two patients that were treated by intensity-modulated radiation therapy (IMRT) or intensity modulated radiosurgery (IMRS) for 43 intracranial lesions, underwent repeated CT imaging during their course of treatment, or as a positional control immediately before radiosurgery. We evaluated multiple anatomical landmark coordinates and their respective shifts in consecutive repeated CT-controls. An iterative optimization algorithm allowed for the calculation of the x, y and z-components of translation of the target isocenter(s) for each repeated CT, as well as rotation in the respective CT data sets. In addition to absolute target isocenter translation, the total magnitude vector (i.e. sum-vector) of isocenter motion was calculated along with patient rotations about the three principle axes.
Fifty-five control CT datasets were analyzed for the target isocenter's respective position relative to the original treatment planning CT simulation. Mean target isocenter translation was 0.74+/-0.53, 0.75+/-0.60 and 0.93+/-0.78 mm in x, y and z-directions, respectively. Mean rotation about the x, y and z-axes was 0.67+/-0.66, 0.61+/-0.63 and 0.67+/-0.61 degrees, respectively. The respective median and mean magnitude vectors of isocenter translation were 1.28 and 1.59+/-0.84 mm. Analysis of the accuracy of the first setup control, representative of setup accuracy for radiosurgery treatments, compared with setup accuracy throughout a fractionated radiation treatment course were statistically equivalent (P= 0.15) thus indicating no measurable deterioration of setup accuracy throughout the treatment course.
The analyzed Orfit thermoplastic mask system performed favorably compared with other mask immobilization systems for which peer-reviewed repositioning data exist. While the performance of the system for fractionated treatment courses was considered to be excellent, use of this mask system for radiosurgery immobilization in our clinic is subject to additional quality assurance measures to prohibit the delivery of treatments with target dislocations larger than 2 mm. The measured data in the present study should enable the users of this system to assign appropriate margins for the generation of planning target volumes.
评估一种市售热塑性面罩系统在单次放射外科治疗和分次治疗疗程中的重新定位精度。
分析了Raycast-HP面罩系统(比利时维涅gem的Orfit Industries公司)的重新定位精度。22例因43个颅内病变接受调强放射治疗(IMRT)或调强放射外科治疗(IMRS)的患者,在治疗过程中或放射外科治疗前立即进行重复CT成像作为位置对照。我们评估了多个解剖标志点坐标及其在连续重复CT对照中的各自移位。一种迭代优化算法可计算每次重复CT中靶等中心的x、y和z轴平移分量,以及各自CT数据集中的旋转。除了绝对靶等中心平移外,还计算了等中心运动向量的总大小(即和向量)以及患者绕三个主轴的旋转。
分析了55个对照CT数据集,以确定靶等中心相对于原始治疗计划CT模拟的各自位置。靶等中心在x、y和z方向的平均平移分别为0.74±0.53、0.75±0.60和0.93±0.78 mm。绕x、y和z轴的平均旋转分别为0.67±0.66、0.61±0.63和0.67±0.61度。等中心平移的各自中位数和平均大小向量分别为1.28和1.59±0.84 mm。将代表放射外科治疗设置精度的首次设置对照的精度与整个分次放射治疗疗程中的设置精度进行分析比较,结果在统计学上等效(P = 0.15),因此表明在整个治疗过程中设置精度没有可测量的下降。
与其他有同行评审重新定位数据的面罩固定系统相比,所分析的Orfit热塑性面罩系统表现良好。虽然该系统在分次治疗疗程中的性能被认为是优秀的,但在我们的诊所中,将此面罩系统用于放射外科固定需要额外的质量保证措施,以防止在靶移位大于2 mm的情况下进行治疗。本研究中的测量数据应能使该系统的使用者为计划靶体积的生成指定适当的边界。