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糖尿病翻译研究:我们现在何处,又想去何方?

Diabetes translation research: where are we and where do we want to be?

作者信息

Narayan K M Venkat, Benjamin Evan, Gregg Edward W, Norris Susan L, Engelgau Michael M

机构信息

Division of Diabetes Translation, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA.

出版信息

Ann Intern Med. 2004 Jun 1;140(11):958-63. doi: 10.7326/0003-4819-140-11-200406010-00037.

Abstract

Translation research transforms currently available knowledge into useful measures for everyday clinical and public health practice. We review the progress in diabetes translation research and identify future challenges and opportunities in this field. Several promising interventions to optimize implementation of efficacious diabetes treatments are available. Many of these interventions, singly or in combination, need to be more formally tested in larger randomized or quasi-experimental practical trials using outcomes of special interest to patients (for example, patient satisfaction and quality of life) and policymakers (for example, cost and cost-effectiveness). The long-term outcomes (such as morbidity, mortality, quality of life, and costs) of strategies aimed at improving diabetes care must be assessed. Translation research also needs to incorporate ways of studying complex systems of care. The challenges and opportunities offered by translation research are tremendous.

摘要

转化研究将现有的知识转化为日常临床和公共卫生实践中有用的措施。我们回顾了糖尿病转化研究的进展,并确定了该领域未来的挑战和机遇。目前有几种有前景的干预措施可用于优化有效糖尿病治疗的实施。这些干预措施中的许多,单独或联合使用,需要在更大规模的随机或准实验性实际试验中进行更正式的测试,使用患者特别感兴趣的结果(例如,患者满意度和生活质量)和政策制定者特别感兴趣的结果(例如,成本和成本效益)。必须评估旨在改善糖尿病护理的策略的长期结果(如发病率、死亡率、生活质量和成本)。转化研究还需要纳入研究复杂护理系统的方法。转化研究带来的挑战和机遇是巨大的。

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