用于大鼠心率和血氧饱和度测量的Nonin 8600V脉搏血氧仪的验证

Validation of the Nonin 8600V Pulse Oximeter for heart rate and oxygen saturation measurements in rats.

作者信息

Bernard Susan L, An Dowon, Glenny Robb W

机构信息

Department of Pulmonary and Critical Care Medicine, University of Washington, Seattle, Washington 98195, USA.

出版信息

Contemp Top Lab Anim Sci. 2004 May;43(3):43-5.

PMID:15174817

Abstract

This report validates the use and limitations of the Nonin Pulse Oximeter for measuring heart rate and oxygen saturation in rats. Eight anesthetized Sprague-Dawley rats were intubated and catheterized. Oxygen saturation was directly measured from arterial blood by using a Radiometer OSM3 Hemoximeter adjusted for rat blood as well as indirectly by using the Nonin Pulse Oximeter. Oxygen saturation was changed by varying the level of inhaled oxygen. Heart rate was measured in two ways: 1) by using the signal from the Nonin Pulse Oximeter and 2) by counting the pressure pulses from the transduced blood pressure. There was excellent agreement between heart rate values measured by the Nonin Pulse Oximeter and that measured by counting the pulses from the arterial blood pressure recording. The Nonin Pulse Oximeter underestimated oxygen saturations by about 3% to 5% compared to the Hemoximeter. Overall, the pulse oximeter reflected important trends in oxygen saturations, making it a useful tool for laboratory animal medicine.

摘要

本报告验证了Nonin脉搏血氧仪在测量大鼠心率和血氧饱和度方面的应用及局限性。八只麻醉后的Sprague-Dawley大鼠进行了插管和导管插入术。使用针对大鼠血液校准的Radiometer OSM3血氧计直接从动脉血中测量血氧饱和度，并使用Nonin脉搏血氧仪间接测量。通过改变吸入氧气水平来改变血氧饱和度。心率通过两种方式测量：1）使用Nonin脉搏血氧仪的信号；2）通过计数经转换的血压中的压力脉冲。Nonin脉搏血氧仪测量的心率值与通过计数动脉血压记录中的脉冲所测量的心率值之间具有极好的一致性。与血氧计相比，Nonin脉搏血氧仪低估了约3%至5%的血氧饱和度。总体而言，脉搏血氧仪反映了血氧饱和度的重要趋势，使其成为实验动物医学的有用工具。