Young Simon S, Skeans Susan M, Lamca James E, Chapman Richard W
Department of Allergy, Schering-Plough Research Institute, Kenilworth, NJ 07033, USA.
Department of Allergy, Schering-Plough Research Institute, Kenilworth, NJ 07033, USA.
Vet Anaesth Analg. 2002 Jul;29(3):150-155. doi: 10.1046/j.1467-2995.2002.00086.x. Epub 2016 Nov 15.
To assess the agreement between three measurements of arterial oxygen saturation (SpO, SaO and ScO) in anesthetized cynomolgus monkeys.
Prospective study.
Eleven mature, male cynomolgus monkeys (Macaca fasicularis).
Monkeys were anesthetized with intramuscular ketamine followed by intravenous propofol. The trachea of each was intubated and the lungs ventilated. Arterial oxygen saturation was measured with a Nonin 8500 V pulse oximeter, using a lingual clip on the cheek. Arterial blood samples were taken from an indwelling catheter. Inspired oxygen concentration was varied from 12 to 20%, and 88 paired arterial blood samples and saturation measurements were taken. Arterial oxygen saturation in the blood samples was measured using a cooximeter. The saturation was also calculated from the arterial oxygen tension using the Adair equation. The results were compared using Bland and Altman's method.
The pulse oximeter readings were 2.7% higher than that of the cooximeter, with a limit of agreement of -3.9 to 9.3%. The pulse oximeter readings were 1.8% higher than the calculated saturation, with a limit of agreement of -6.5% to 10.1%. The cooximeter readings were 0.9% lower than the calculated saturation, with a limit of agreement of -5.6% to 3.8%.
The agreement between SpO and other measurements of arterial oxygen saturation in this study is typical for this technique. The bias and limits of agreement are consistent with reports in other species.
The Nonin 8500 V is a useful pulse oximeter for clinical use in primates.
评估麻醉食蟹猴动脉血氧饱和度（SpO、SaO和ScO）三种测量方法之间的一致性。
前瞻性研究。
11只成年雄性食蟹猴（食蟹猕猴）。
用肌肉注射氯胺酮麻醉猴子，随后静脉注射丙泊酚。每只猴子气管插管并进行肺通气。使用Nonin 8500 V脉搏血氧仪，通过脸颊上的舌夹测量动脉血氧饱和度。从留置导管采集动脉血样本。吸入氧浓度在12%至20%之间变化，共采集88对动脉血样本和饱和度测量值。使用血氧计测量血样本中的动脉血氧饱和度。还使用阿代尔方程根据动脉氧分压计算饱和度。使用布兰德和奥特曼方法比较结果。
脉搏血氧仪读数比血氧计读数高2.7%，一致性界限为-3.9%至9.3%。脉搏血氧仪读数比计算出的饱和度高1.8%，一致性界限为-6.5%至10.1%。血氧计读数比计算出的饱和度低0.9%，一致性界限为-5.6%至3.8%。
本研究中SpO与其他动脉血氧饱和度测量方法之间的一致性是该技术的典型情况。偏差和一致性界限与其他物种的报告一致。
Nonin 8500 V是一种用于灵长类动物临床的有用脉搏血氧仪。
