Agreement of SpO, SaO and ScO in anesthetized cynomolgus monkeys (Macaca fascicularis).

OBJECTIVE

To assess the agreement between three measurements of arterial oxygen saturation (SpO, SaO and ScO) in anesthetized cynomolgus monkeys.

STUDY DESIGN

Prospective study.

ANIMALS

Eleven mature, male cynomolgus monkeys (Macaca fasicularis).

METHODS

Monkeys were anesthetized with intramuscular ketamine followed by intravenous propofol. The trachea of each was intubated and the lungs ventilated. Arterial oxygen saturation was measured with a Nonin 8500 V pulse oximeter, using a lingual clip on the cheek. Arterial blood samples were taken from an indwelling catheter. Inspired oxygen concentration was varied from 12 to 20%, and 88 paired arterial blood samples and saturation measurements were taken. Arterial oxygen saturation in the blood samples was measured using a cooximeter. The saturation was also calculated from the arterial oxygen tension using the Adair equation. The results were compared using Bland and Altman's method.

RESULTS

The pulse oximeter readings were 2.7% higher than that of the cooximeter, with a limit of agreement of -3.9 to 9.3%. The pulse oximeter readings were 1.8% higher than the calculated saturation, with a limit of agreement of -6.5% to 10.1%. The cooximeter readings were 0.9% lower than the calculated saturation, with a limit of agreement of -5.6% to 3.8%.

CONCLUSIONS

The agreement between SpO and other measurements of arterial oxygen saturation in this study is typical for this technique. The bias and limits of agreement are consistent with reports in other species.

CLINICAL RELEVANCE

The Nonin 8500 V is a useful pulse oximeter for clinical use in primates.