多羟基化近红外碳菁分子探针的合成与评价

Synthesis and evaluation of polyhydroxylated near-infrared carbocyanine molecular probes.

作者信息

Zhang Zongren, Achilefu Samuel

机构信息

Department of Radiology, Washington University, St. Louis, Missouri 63110, USA.

出版信息

Org Lett. 2004 Jun 10;6(12):2067-70. doi: 10.1021/ol049258a.

DOI:10.1021/ol049258a

PMID:15176820

Abstract

[reaction: see text] A new near-infrared (NIR) fluorescent molecular probe derived from indocarbocyanine dye and galactose was prepared, and the procedure was optimized. The presence of a nonionic polyhydroxyl moiety between hydrophobic groups enhances solubility and possibly minimizes aggregation in aqueous solutions. The structural framework of this molecule provides multivalent sites for labeling diverse molecules.

摘要

[反应：见正文] 制备了一种源自吲哚碳菁染料和半乳糖的新型近红外（NIR）荧光分子探针，并对该过程进行了优化。疏水基团之间存在非离子多羟基部分可提高溶解度，并可能使水溶液中的聚集最小化。该分子的结构框架为标记各种分子提供了多价位点。