一种基于苯并噻唑的焦磷酸（PPi）和三磷酸腺苷（ATP）传感器：阴离子诱导的激发态分子内质子转移开启的机理洞察
A Benzothiazole-Based Sensor for Pyrophosphate (PPi) and ATP: Mechanistic Insight for Anion-Induced ESIPT Turn-On.
作者信息
Wang Junfeng, Liu Xiumin, Pang Yi
机构信息
Department of Chemistry, The University of Akron, Akron, Ohio 44325 U.S.A.
Department of Chemistry, The University of Akron, Akron, Ohio 44325 U.S.A ; Maurice Morton Institute of Polymer Science, The University of Akron, Akron, Ohio 44325 U.S.A.
出版信息
J Mater Chem B. 2014 Oct 14;2(38):6634-6638. doi: 10.1039/C4TB01109K.
Abstract
A benzothiazole derivative 2 bearing two 2,2'-dipicolylamine (DPA) groups was examined for its zinc-binding and subsequent anion sensing properties. The study revealed the anion sensing mechanism of polyphosphate anions via sequential binding to two zinc centers, on the basis of both H NMR and mass spectral evidences. The mechanistic insight would provide valuable information for the future design of new excited state intramolecular proton transfer (ESIPT) sensors. In addition, the zinc complex exhibited the solvent-switchible selectivity, responding to pyrophosphate (PPi) in EtOH but adenosine 5'-triphosphate (ATP) in water.
摘要
对带有两个2,2'-联吡啶胺（DPA）基团的苯并噻唑衍生物2进行了锌结合及后续阴离子传感性能研究。基于核磁共振氢谱（H NMR）和质谱证据，该研究揭示了多磷酸根阴离子通过依次与两个锌中心结合的阴离子传感机制。这一机理见解将为未来新型激发态分子内质子转移（ESIPT）传感器的设计提供有价值的信息。此外，锌配合物表现出溶剂可切换的选择性，在乙醇中对焦磷酸（PPi）有响应，而在水中对腺苷5'-三磷酸（ATP）有响应。
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