Mansuetta Cheri C, Mason John O, Swanner Jason, Feist Richard M, White Milton F, Thomley Martin L, McGwin Gerald, Emond Tracy L
University of Alabama at Birmingham, Department of Ophthalmology, USA.
Am J Ophthalmol. 2004 Jun;137(6):1096-100. doi: 10.1016/j.ajo.2004.01.054.
To explore a clinically observed association between central serous chorioretinopathy (CSC) and gastroesophageal reflux disease (GERD) DESIGN: A retrospective case-control study.
Sixty-nine consecutive patients diagnosed with CSC were compared with a control group of 55 non-CSC patients.
The records of 69 patients with CSC were retrospectively reviewed and compared with the records of 55 controls. All patients and controls were examined in a referral setting.
Patients with CSC were significantly more likely to have GERD compared with controls (odds ratio 6.05; 95% confidence interval 2.14-17.11; P =.0003). Central serous chorioretinopathy patients were also more likely than controls to have used oral corticosteroid medications (odds ratio 16.30; 95% confidence interval 2.09-127.33; P =.0006) and antacid/antireflux medications (odds ratio 15.00; 95% confidence interval 1.91-117.58; P =.001).
This study identifies an association between CSC and GERD. There are biochemical factors common to both diseases that support this association, giving further insight into the pathogenesis of CSC.
探讨临床上观察到的中心性浆液性脉络膜视网膜病变（CSC）与胃食管反流病（GERD）之间的关联。
一项回顾性病例对照研究。
69例连续诊断为CSC的患者与55例非CSC患者的对照组进行比较。
对69例CSC患者的记录进行回顾性审查，并与55例对照组的记录进行比较。所有患者和对照组均在转诊机构接受检查。
与对照组相比，CSC患者患GERD的可能性显著更高（比值比6.05；95%置信区间2.14 - 17.11；P = 0.0003）。CSC患者使用口服皮质类固醇药物的可能性也高于对照组（比值比16.30；95%置信区间2.09 - 127.33；P = 0.0006）以及使用抗酸/抗反流药物的可能性（比值比15.00；95%置信区间1.91 - 117.58；P = 0.001）。
本研究确定了CSC与GERD之间的关联。两种疾病存在共同的生化因素支持这一关联，为CSC的发病机制提供了进一步的见解。
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