Piccolino Felice Cardillo, De La Longrais Roberta Rigault, Manea Marilisa, Cicinelli Simonetta, Ravera Giambattista
Fondazione per la Macula Onlus, Genova.
Retina. 2008 Oct;28(8):1146-50. doi: 10.1097/IAE.0b013e318175421f.
To identify factors associated with the development of posterior cystoid retinal degeneration (PCRD) in central serous chorioretinopathy (CSC).
The authors retrospectively studied 51 eyes of 51 patients with chronic CSC and subretinal or intraretinal exudation documented by optical coherence tomography (OCT), and evaluated the association of hypertension, systemic use of corticosteroids, duration of symptoms, subretinal fibrosis, and large laser scars with the development of PCRD.
Twenty-four eyes (47%) had PCRD and 27 eyes (53%) had serous macular detachment without cystoid retinal changes. Multivariate analysis showed that a duration of symptoms exceeding 5 years (odds ratio [OR], 25.4; 95% confidence interval [CI], 2.8-233.2; P = 0.004) and subretinal fibrosis (OR, 19.1; 95% CI, 1.8-205.1; P = 0.015) were significantly associated with PCRD.
Disease duration longer than 5 years and subretinal fibrosis are associated with the development of PCRD in CSC. Prospective evaluations could substantiate the associations found in this study and further clarify their significance.
确定中心性浆液性脉络膜视网膜病变（CSC）中与后部囊样视网膜变性（PCRD）发生相关的因素。
作者回顾性研究了51例慢性CSC患者的51只眼，这些患者经光学相干断层扫描（OCT）记录有视网膜下或视网膜内渗出，并评估高血压、全身性使用皮质类固醇、症状持续时间、视网膜下纤维化和大面积激光瘢痕与PCRD发生之间的关联。
24只眼（47%）发生了PCRD，27只眼（53%）有浆液性黄斑脱离但无囊样视网膜改变。多因素分析显示，症状持续时间超过5年（比值比[OR]，25.4；95%置信区间[CI]，2.8 - 233.2；P = 0.004）和视网膜下纤维化（OR，19.1；95%CI，1.8 - 205.1；P = 0.015）与PCRD显著相关。
病程超过5年和视网膜下纤维化与CSC中PCRD的发生相关。前瞻性评估可以证实本研究中发现的关联，并进一步阐明其意义。
