一种在玻璃上的自组装单分子层上进行传感器发现与制造的简单方法。

A simple approach to sensor discovery and fabrication on self-assembled monolayers on glass.

作者信息

Basabe-Desmonts Lourdes, Beld Joris, Zimmerman Rebecca S, Hernando Jordi, Mela Petra, García Parajó María F, van Hulst Niek F, van den Berg Albert, Reinhoudt David N, Crego-Calama Mercedes

机构信息

Department of Supramolecular Chemistry and Technology, Applied Optics Group, Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands.

出版信息

J Am Chem Soc. 2004 Jun 16;126(23):7293-9. doi: 10.1021/ja049901o.

DOI:10.1021/ja049901o

PMID:15186166

Abstract

Self-assembled monolayers (SAMs) on glass were used as a platform to sequentially deposit fluorophores and small molecules for ion sensing. The preorganization provided by the surface avoids the need for complex receptor design, allowing for a combinatorial approach to sensing systems based on small molecules. The resulting libraries are easily measured and show varied responses to a series of both cations and anions. This technology is transferable from the macro- to the microscale both via microcontact printing (microCP), where the fluorophore is printed onto a glass surface, and via direct attachment of the fluorophore to microchannel walls. The ease of miniaturization of this technology may make the generation of a wide variety of simple yet efficient microarrays possible.

摘要

玻璃上的自组装单分子层（SAMs）被用作一个平台，用于依次沉积荧光团和小分子以进行离子传感。表面提供的预组织避免了复杂受体设计的需求，从而允许基于小分子的传感系统采用组合方法。由此产生的文库易于测量，并且对一系列阳离子和阴离子都表现出不同的响应。这项技术既可以通过微接触印刷（microCP）从宏观尺度转移到微观尺度，即将荧光团印刷到玻璃表面，也可以通过将荧光团直接附着到微通道壁上来实现。该技术易于小型化，这可能使生成各种各样简单而高效的微阵列成为可能。