Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566, Japan.
DAILAB, DBT-AIST International Center for Translational and Environmental Research (DAICENTER), National Institute of Advanced Industrial Science and Technology (AIST), Central 5-41, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8565, Japan.
Sensors (Basel). 2020 Apr 15;20(8):2228. doi: 10.3390/s20082228.
Synthetic sensing materials (artificial receptors) are some of the most attractive components of chemical/biosensors because of their long-term stability and low cost of production. However, the strategy for the practical design of these materials toward specific molecular recognition in water is not established yet. For the construction of artificial material-based chemical/biosensors, the bottom-up assembly of these materials is one of the effective methods. This is because the driving forces of molecular recognition on the receptors could be enhanced by the integration of such kinds of materials at the 'interfaces', such as the boundary portion between the liquid and solid phases. Additionally, the molecular assembly of such self-assembled monolayers (SAMs) can easily be installed in transducer devices. Thus, we believe that nanosensor platforms that consist of synthetic receptor membranes on the transducer surfaces can be applied to powerful tools for high-throughput analyses of the required targets. In this review, we briefly summarize a comprehensive overview that includes the preparation techniques for molecular assemblies, the characterization methods of the interfaces, and a few examples of receptor assembly-based chemical/biosensing platforms on each transduction mechanism.
合成传感材料（人工受体）因其长期稳定性和低成本的生产而成为化学/生物传感器中最具吸引力的组成部分之一。然而，针对特定分子在水中的实际设计这些材料的策略尚未建立。对于基于人工材料的化学/生物传感器的构建，这些材料的自下而上组装是一种有效的方法。这是因为通过在“界面”（例如液相和固相之间的边界部分）处整合这种材料，可以增强分子识别在受体上的驱动力。此外，这种自组装单层（SAM）的分子组装可以轻松地安装在换能器设备中。因此，我们相信，由换能器表面上的合成受体膜组成的纳米传感器平台可以应用于高通量分析所需目标的强大工具。在这篇综述中，我们简要总结了一个全面的概述，包括分子组装的制备技术、界面的表征方法以及每个换能机制基于受体组装的化学/生物传感平台的几个示例。
