氨溴索对兔咽鼓管表面活性物质的影响。

Effect of ambroxol on rabbit eustachian tube surfactant.

作者信息

Mira E, Benazzo M, Manzoni M, Lligona L, Salmona M, Tacconi M T

机构信息

Clinica Otorinolaringoiatrica, Università di Pavia, Italia.

出版信息

ORL J Otorhinolaryngol Relat Spec. 1992;54(3):130-2. doi: 10.1159/000276281.

DOI:10.1159/000276281

PMID:1518659

Abstract

The effect of ambroxol administration on phospholipid and phosphatidyl-choline contents of rabbit eustachian tube and lung washings and on [14C]-choline incorporation by rabbit eustachian tube and lung tissue has been studied. Despite minor differences, the drug exerts the same activating effect in both locations. The results add a further piece of evidence to the several similarities existing between the lung surfactant and the surface-active substances present on the eustachian tube.

摘要

研究了氨溴索给药对兔咽鼓管和肺灌洗液中磷脂和磷脂酰胆碱含量以及对兔咽鼓管和肺组织中[14C]-胆碱掺入的影响。尽管存在细微差异，但该药物在两个部位均发挥相同的激活作用。这些结果为肺表面活性物质和咽鼓管中存在的表面活性物质之间现有的若干相似性增添了又一证据。