Mira E, Benazzo M, Tacconi M T, Lligona L, Fumagalli G F, Salmona M
Clinica Otorinolaringoiatrica dell' Università di Pavia, Italia.
ORL J Otorhinolaryngol Relat Spec. 1990;52(3):174-9. doi: 10.1159/000276129.
A chemical analysis of phospholipids in rabbit Eustachian tube and in its lavages shows phosphatidylcholine (PC) as being the predominating compound, followed by sphingomyelin and phosphatidylethanolamine. As in the lung surfactant, the majority of tubal PC is represented by its disaturated form dipalmitoylphosphatidylcholine (DPPC), known as a powerful surface-active agent. The concentration of PC and DPPC is higher in tubal washing than in the whole tissue, suggesting the existence of an active secretory process. Incubation of tubal mucosa with 14C-choline resulted in the biosynthesis of radiolabelled PC and DPPC at a ratio similar to the lung. These data provide further evidence for the existence of a surface-active agent in the Eustachian tube, chemically similar to the lung surfactant and probably produced through similar metabolic pathways.
对兔咽鼓管及其灌洗液中磷脂的化学分析表明，磷脂酰胆碱（PC）是主要成分，其次是鞘磷脂和磷脂酰乙醇胺。与肺表面活性物质一样，咽鼓管中的大部分PC以其双饱和形式二棕榈酰磷脂酰胆碱（DPPC）存在，DPPC是一种强大的表面活性剂。咽鼓管灌洗液中PC和DPPC的浓度高于整个组织，这表明存在活跃的分泌过程。用14C-胆碱孵育咽鼓管黏膜，会以与肺相似的比例生物合成放射性标记的PC和DPPC。这些数据进一步证明了咽鼓管中存在一种表面活性剂，其化学性质与肺表面活性物质相似，可能通过相似的代谢途径产生。
