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人类基因组中的蛋白质酪氨酸磷酸酶。

Protein tyrosine phosphatases in the human genome.

作者信息

Alonso Andres, Sasin Joanna, Bottini Nunzio, Friedberg Ilan, Friedberg Iddo, Osterman Andrei, Godzik Adam, Hunter Tony, Dixon Jack, Mustelin Tomas

机构信息

Program of Signal Transduction, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.

出版信息

Cell. 2004 Jun 11;117(6):699-711. doi: 10.1016/j.cell.2004.05.018.

DOI:10.1016/j.cell.2004.05.018

PMID:15186772

Abstract

Tyrosine phosphorylation is catalyzed by protein tyrosine kinases, which are represented by 90 genes in the human genome. Here, we present the set of 107 genes in the human genome that encode members of the four protein tyrosine phosphatase (PTP) families. The four families of PTPases, their substrates, structure, function, regulation, and the role of these enzymes in human disease will be discussed.

摘要

酪氨酸磷酸化由蛋白酪氨酸激酶催化，人类基因组中有90个基因代表蛋白酪氨酸激酶。在此，我们展示了人类基因组中编码四个蛋白酪氨酸磷酸酶（PTP）家族成员的107个基因集。我们将讨论PTP酶的四个家族、它们的底物、结构、功能、调节以及这些酶在人类疾病中的作用。