Yuan Shuanghu, Xu Sifan, Yang Xinhua, Liu Xiuqing, Hao Junfang, Qian Ming
Department of Radiology, Shandong Tumor Hospital & Institute, Jinan, Shandong 250117, China.
Zhonghua Nan Ke Xue. 2004 May;10(5):345-7, 350.
To investigate the effects of c-jun on hCG-induced testosterone secretion in isolated rat Leydig cells by antisense oligodeoxynucleotides(ASODNs).
c-jun ASODNs were used to antagonise the effects of c-jun, hCG was used to induce the testosterone secretion of LC cultured in vitro and testosterone was measured by radioimmunoassay.
The testosterone secretion of LC in vitro could be induced by hCG, which was a good model for the functional study of LC. c-jun ASODNs decreased the hCG-induced testosterone secretion of LC in a dose-dependent manner(P < 0.05).
It is suggested that c-jun proto-oncogene enhances the testosterone secretion of LC.
