[前列腺癌中表达的前列腺六跨膜上皮抗原的临床意义]
[Clinical significance of six-transmembrane epithelial antigen of the prostate expressed in prostatic carcinoma].
作者信息
Li Liaoyuan, Li Jiefang, Shen Zhoujun, Liu Weijun, Chen Zhaodian
机构信息
Department of Urology, First Affiliated Hospital, Zhejiang University Medical College, Hangzhou, Zhejiang 310003, China.
出版信息
Zhonghua Nan Ke Xue. 2004 May;10(5):351-4.
OBJECTIVE
To investigate the relationship between six-transmembrane epithelial antigen of the prostate (STEAP) expression and the histologic grading of prostatic carcinoma (PCa).
METHODS
Different prostatic tissues and non-prostatic tumors, 131 cases of PCa, 164 cases of benign prostate hyperplasia (BPH), and 56 cases of non-prostatic malignancies, were analyzed for the expression of STEAP by using STEAP monoclonal antibody and SP immunohistochemical staining. The positive area unit (PU) was introduced to describe the intensity of STEAP expression.
RESULTS
The prostatic tissues of all but 3 cases of PCa and 5 cases of BPH were stained positively, while all of the non-prostatic tumors were stained negatively. There was a significant negative correlation between the STEAP expression and the histologic grading of PCa.
CONCLUSION
STEAP can be a prognostic marker of PCa and a potential therapeutic target in PCa.
目的
探讨前列腺六跨膜上皮抗原（STEAP）表达与前列腺癌（PCa）组织学分级之间的关系。
方法
采用STEAP单克隆抗体及SP免疫组化染色法，分析131例PCa、164例良性前列腺增生（BPH）及56例非前列腺恶性肿瘤等不同前列腺组织及非前列腺肿瘤中STEAP的表达情况。引入阳性面积单位（PU）描述STEAP表达强度。
结果
除3例PCa和5例BPH外，所有前列腺组织均呈阳性染色，而所有非前列腺肿瘤均呈阴性染色。PCa的STEAP表达与组织学分级之间存在显著负相关。
结论
STEAP可作为PCa的预后标志物及PCa潜在的治疗靶点。
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