El Kamar F G, Jindal K, Grossbard M L, Mizrachi H H, Kozuch P S
St. Luke's-Roosevelt Hospital Center, Columbia University College of Physicians & Surgeons, 1000 Tenth Avenue, Suite 11 G, New York, NY 10019, USA.
Dig Liver Dis. 2004 May;36(5):355-60. doi: 10.1016/j.dld.2003.10.019.
The case of a patient developing multiple brain metastases from carcinoma of the exocrine pancreas has been described. A 56-year-old man with stage IV pancreatic cancer attained a clinical and radiographic response while receiving the G-FLIP chemotherapy regimen (biweekly gemcitabine, irinotecan, 5-fluorouracil, leucovorin and cisplatin). After 4 months of therapy, he developed gait imbalance and weakness in the right hand. An MRI of the brain showed multiple 1-2 mm enhancing nodules in the cerebral hemispheres and pons. A subsequent biopsy confirmed that these were pancreatic carcinoma metastases. The patient experienced a rapid deterioration in his neurological status and died 3 days after brain biopsy. Previously reported cases of brain metastases from pancreatic cancer are reviewed.
已描述了1例来自外分泌性胰腺癌的患者发生多发性脑转移的病例。一名56岁的IV期胰腺癌男性患者在接受G-FLIP化疗方案（每两周一次吉西他滨、伊立替康、5-氟尿嘧啶、亚叶酸钙和顺铂）治疗时获得了临床和影像学缓解。治疗4个月后，他出现步态失衡和右手无力。脑部MRI显示大脑半球和脑桥有多个1-2mm强化结节。随后的活检证实这些是胰腺癌转移灶。患者神经功能状态迅速恶化，在脑活检后3天死亡。对先前报道的胰腺癌脑转移病例进行了综述。
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