尼古丁戒断大鼠中腹侧被盖区多巴胺神经元活动的降低
Decrease of ventral tegmental area dopamine neuronal activity in nicotine withdrawal rats.
作者信息
Liu Zhong-Hua, Jin Wen-Qiao
机构信息
Department of Pharmacology, Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China.
出版信息
Neuroreport. 2004 Jun 28;15(9):1479-81. doi: 10.1097/01.wnr.0000126218.25235.b6.
The present study was designed to examine the ventral tegmental area (VTA) dopamine neuronal activity in nicotine withdrawal rats by means of in vivo single-unit extracellular recordings. Animals were treated with nicotine base (6 mg/kg/day, s.c.) four times daily for 12 days. One day after the last nicotine administration, the firing rates of the VTA dopamine neurons were found to be significantly decreased. Following 2, 3, 5 and 10 days of nicotine withdrawal, however, the firing rates returned to the control levels. The number of spontaneously active dopamine cells was not altered at any time points. The results indicate that the VTA dopamine neuronal activity is reduced during the first day of nicotine withdrawal.
本研究旨在通过体内单细胞胞外记录来检测尼古丁戒断大鼠腹侧被盖区（VTA）多巴胺能神经元的活动。动物每天皮下注射4次尼古丁碱（6 mg/kg/天），持续12天。在最后一次注射尼古丁后的第1天，发现VTA多巴胺能神经元的放电频率显著降低。然而，在尼古丁戒断2、3、5和10天后，放电频率恢复到对照水平。在任何时间点，自发活动的多巴胺能细胞数量均未改变。结果表明，在尼古丁戒断的第一天，VTA多巴胺能神经元的活动减少。
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