在多形汉逊酵母中，微自噬和大定点自噬可能同时发生。

Microautophagy and macropexophagy may occur simultaneously in Hansenula polymorpha.

作者信息

Monastryska Iryna, Sjollema Klaas, van der Klei Ida J, Kiel Jan A K W, Veenhuis Marten

机构信息

Laboratory of Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, P.O. Box 14, 9750 AA Haren, The Netherlands.

出版信息

FEBS Lett. 2004 Jun 18;568(1-3):135-8. doi: 10.1016/j.febslet.2004.05.018.

DOI:10.1016/j.febslet.2004.05.018

PMID:15196934

Abstract

We subjected methanol-grown cells of wild type Hansenula polymorpha simultaneously to nitrogen depletion and excess glucose conditions. Both treatments induce the degradation of peroxisomes, either selective (via excess glucose) or non-selective (via nitrogen limitation). Our combined data strongly suggest that both processes occur simultaneously under these conditions. The implications of these findings on studies of autophagy and related transport pathways to the vacuole in yeast are discussed.

摘要

我们将甲醇培养的野生型多形汉逊酵母细胞同时置于氮缺乏和葡萄糖过量的条件下。这两种处理都会诱导过氧化物酶体的降解，一种是选择性的（通过葡萄糖过量），另一种是非选择性的（通过氮限制）。我们的综合数据有力地表明，在这些条件下这两个过程同时发生。本文讨论了这些发现对酵母自噬及相关液泡转运途径研究的意义。