Mahony M J, Wyatt J I, Littlewood J M
Department of Paediatrics, St James's University Hospital, Leeds.
Arch Dis Child. 1992 Jul;67(7):940-3. doi: 10.1136/adc.67.7.940.
Gastritis associated with Helicobacter pylori was present in gastric biopsies from 24/95 (25%) children and adolescents undergoing endoscopy for recurrent abdominal pain and upper gastrointestinal symptoms. H pylori associated gastritis occurred mainly in older children (8-16 years) and was significantly associated with low socioeconomic class and a family history of peptic ulcer disease. Antral nodularity was a common endoscopic finding in H pylori positive children. Eighteen children, all over 5 years of age, were treated with tripotassium dicitratobismuthate (De-Nol) for two months and ampicillin for two weeks. In 12 children follow up gastric biopsies were obtained six weeks after completion of treatment. In 9/12 (75%) children H pylori was eradicated, and gastritis improved.
在接受内镜检查以评估反复腹痛和上消化道症状的95名儿童和青少年中，24例（25%）的胃活检显示存在与幽门螺杆菌相关的胃炎。幽门螺杆菌相关胃炎主要发生在年龄较大的儿童（8 - 16岁）中，并且与社会经济地位低下以及消化性溃疡疾病家族史显著相关。胃窦结节是幽门螺杆菌阳性儿童常见的内镜检查发现。18名年龄均超过5岁的儿童接受了两个月的枸橼酸铋钾（得乐）治疗和两周的氨苄青霉素治疗。12名儿童在治疗结束六周后进行了随访胃活检。在12名儿童中的9名（75%），幽门螺杆菌被根除，胃炎得到改善。
