Mitsuhashi Takashi, Watanabe Mitsuya, Ohara Yukoh, Hatashita Shizuo, Ueno Hideo
Department of Neurosurgery, Juntendo University, Juntendo Urayasu Hospital, Urayasu, Chiba.
Neurol Med Chir (Tokyo). 2004 May;44(5):249-54. doi: 10.2176/nmc.44.249.
A 58-year-old female presented with a unique case of multifocal primary intracerebral malignant fibrous histiocytoma (MFH) manifesting as partial seizure. Neuroimaging showed a mass lesion in the right frontal lobe, which was totally removed. The histological diagnosis was MFH. Follow-up neuroimaging one month after surgery showed another lesion rapidly growing in the left frontal lobe. This lesion was totally removed, and identified as MFH. Her condition gradually worsened. Neuroimaging performed 3 months after first operation revealed bilateral recurrence. She died of respiratory failure 7 months after the initial diagnosis of MFH. Primary intracranial MFH is an extremely rare entity with only 31 cases of solitary tumor previously reported.
一名58岁女性出现了多灶性原发性脑内恶性纤维组织细胞瘤（MFH）的独特病例，表现为部分性癫痫发作。神经影像学检查显示右侧额叶有一个肿块病变，该病变被完全切除。组织学诊断为MFH。术后1个月的随访神经影像学检查显示左侧额叶有另一个病变迅速生长。该病变被完全切除，并确诊为MFH。她的病情逐渐恶化。首次手术后3个月进行的神经影像学检查显示双侧复发。在最初诊断为MFH后7个月，她死于呼吸衰竭。原发性颅内MFH是一种极其罕见的疾病，此前仅报道过31例孤立性肿瘤病例。
