Rhodium(I)-catalyzed ene-allene carbocyclization strategy for the formation of azepines and oxepines.
作者信息
Brummond Kay M, Chen Hongfeng, Mitasev Branko, Casarez Anthony D
机构信息
Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
出版信息
Org Lett. 2004 Jun 24;6(13):2161-3. doi: 10.1021/ol049390a.
PMID:15200310
Abstract
[reaction: see text] A novel strategy for the preparation of seven-membered heterocyclic compounds has been realized. Treatment of ene-allene 1 with a catalytic quantity of rhodium biscarbonyl chloride dimer affords the cyclization product 2 in moderate to high yields. The scope and limitations of this new method are currently under investigation, and the results obtained to date are discussed within.
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