通过连锁分析和连锁不平衡分析对牛6号染色体上产奶量QTL进行精细定位。

Fine mapping of milk production QTL on BTA6 by combined linkage and linkage disequilibrium analysis.

作者信息

Olsen H G, Lien S, Svendsen M, Nilsen H, Roseth A, Aasland Opsal M, Meuwissen T H E

机构信息

Department of Animal and Aquacultural Sciences, Agricultural University of Norway, N-1432 Aas, Norway.

出版信息

J Dairy Sci. 2004 Mar;87(3):690-8. doi: 10.3168/jds.S0022-0302(04)73212-9.

DOI:10.3168/jds.S0022-0302(04)73212-9

PMID:15202654

Abstract

Combined linkage and linkage disequilibrium analysis were used to refine the position of a previously detected QTL affecting milk production traits on bovine chromosome 6. Through a series of single- and multitrait and single- and multipoint QTL analyses, the QTL could be positioned to a 7.5-cM interval surrounded by the markers BMS2508 and FBN12. The most significant results were found for fat percentage and protein percentage. This effect seemed to be caused by a QTL allele embedded in one specific marker haplotype that caused a reduction in fat and protein yields and a concomitant increase of milk yield, thus resulting in a marked reduction of fat and protein percentages.

摘要

采用连锁分析和连锁不平衡分析相结合的方法，对先前检测到的影响牛6号染色体产奶性状的QTL进行定位优化。通过一系列单性状和多性状、单标记和多标记QTL分析，该QTL可定位在标记BMS2508和FBN12之间7.5厘摩的区间内。在乳脂率和乳蛋白率方面获得了最显著的结果。这种效应似乎是由一个特定标记单倍型中嵌入的QTL等位基因引起的，该等位基因导致乳脂和乳蛋白产量降低，同时产奶量增加，从而使乳脂率和乳蛋白率显著降低。