Suppr超能文献

颈部肌张力障碍中体感皮层的去抑制——高频振荡幅度降低

Disinhibition of the somatosensory cortex in cervical dystonia-decreased amplitudes of high-frequency oscillations.

作者信息

Inoue Ken, Hashimoto Isao, Shirai Takushi, Kawakami Hideshi, Miyachi Takafumi, Mimori Yasuyo, Matsumoto Masayasu

机构信息

Department of Clinical Neuroscience and Therapeutics, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan.

出版信息

Clin Neurophysiol. 2004 Jul;115(7):1624-30. doi: 10.1016/j.clinph.2004.02.006.

Abstract

OBJECTIVE

To determine whether patients with cervical dystonia have electrophysiological signs of disinhibition in the somatosensory cortex by recording high-frequency oscillations (HFOs) in somatosensory evoked potentials (SEPs).

METHODS

HFOs were recorded in 13 patients and 10 age-matched control subjects, and the data were analyzed statistically by paired comparison and by Pearson's correlation.

RESULTS

In patients with cervical dystonia, the early part of HFOs showed a significant decrease in amplitude, and the amplitude ratios of both early and late parts of HFOs/N20 potential were also significantly decreased. The amplitudes of HFOs and N20 potential were linearly correlated in the control subjects but not in dystonia patients.

CONCLUSIONS

Patients with cervical dystonia may suffer from a disturbance of inhibition in the sensory cortex. This disturbance is reflected by decreased HFO amplitude, representing decreased activities of inhibitory interneurons in area 3b.

摘要

目的

通过记录体感诱发电位(SEP)中的高频振荡(HFO),确定颈部肌张力障碍患者的体感皮层是否存在去抑制的电生理迹象。

方法

记录了13例患者和10名年龄匹配的对照受试者的HFO,并通过配对比较和Pearson相关性对数据进行统计学分析。

结果

在颈部肌张力障碍患者中,HFO的早期部分振幅显著降低,HFO/N20电位早期和晚期部分的振幅比也显著降低。在对照受试者中,HFO和N20电位的振幅呈线性相关,但在肌张力障碍患者中并非如此。

结论

颈部肌张力障碍患者可能存在感觉皮层抑制功能紊乱。这种紊乱表现为HFO振幅降低,提示3b区抑制性中间神经元活动减少。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验