Department of Neurosciences, Catholic University, Rome, Italy.
Clin Neurophysiol. 2012 Oct;123(10):2050-6. doi: 10.1016/j.clinph.2012.03.009. Epub 2012 May 1.
It has been demonstrated that the early part of 600 Hz High Frequency Oscillations (HFOs), probably generated in the terminal part of thalamo-cortical somatosensory radiations, are abnormally reduced between attacks in migraineurs. We aimed at verifying whether spontaneous clinical fluctuations in migraine are correlated to HFO changes.
We recorded somatosensory evoked potentials in 28 migraine patients. Clinical fluctuations (number of attacks in the 6 months preceding and following the test) were correlated to the HFOs' amplitudes. Moreover, eight out of 28 patients underwent a longer follow-up, including HFO control and clinical observation during the 12 months following the baseline recording.
The amplitude of early presynaptic HFOs was significantly correlated to the clinical evolution, since spontaneous worsening was associated with reduced presynaptic HFOs, whereas spontaneous improvement was associated with enhanced presynaptic HFOs (correlation test, p<0.05). No correlation was found between the amplitude of postsynaptic HFOs and clinical fluctuations. Patients undergoing longer follow-up showed substantially unchanged HFOs, accordingly with their stable clinical condition.
HFOs' enhancement in spontaneously improved patients can reflect the increased activity of brainstem arousal related structures, which in turn increases the thalamo-cortical drive and the cortical lateral inhibition mediated by GABAergic interneurons.
HFOs' recording could represent a useful tool in the functional assessment of migraine.
已有研究表明，高频振荡（HFOs）的早期部分可能在丘脑-皮质体感辐射的末端产生，在偏头痛患者发作之间异常减少。我们旨在验证偏头痛的自发性临床波动是否与 HFO 变化相关。
我们在 28 名偏头痛患者中记录了体感诱发电位。将临床波动（测试前和测试后 6 个月内的发作次数）与 HFO 幅度相关联。此外，28 名患者中的 8 名进行了更长时间的随访，包括 HFO 控制和基线记录后 12 个月的临床观察。
早期突触前 HFO 的振幅与临床演变显著相关，因为自发性恶化与突触前 HFO 减少相关，而自发性改善与突触前 HFO 增强相关（相关检验，p<0.05）。突触后 HFO 的振幅与临床波动之间没有相关性。进行更长时间随访的患者显示 HFO 基本不变，与他们稳定的临床状况相符。
自发性改善患者 HFO 的增强可以反映脑干觉醒相关结构活动的增加，进而增加丘脑-皮质驱动和 GABA 能中间神经元介导的皮质外侧抑制。
HFO 记录可能是偏头痛功能评估的有用工具。
