利用对胡桃醌抗性的选择来分离秀丽隐杆线虫中的长寿突变体。
Isolation of long-lived mutants in Caenorhabditis elegans using selection for resistance to juglone.
作者信息
de Castro Edouard, Hegi de Castro Sarah, Johnson Thomas E
机构信息
Institute for Behavioral Genetics, University of Colorado at Boulder, 80309, USA.
出版信息
Free Radic Biol Med. 2004 Jul 15;37(2):139-45. doi: 10.1016/j.freeradbiomed.2004.04.021.
The accumulation of molecular damage from attack by reactive oxygen species is one cause of aging. Therefore, some mutant organisms showing increased resistance to reactive oxygen species should live longer. We show that selection for Caenorhabditis elegans mutants that are resistant to juglone, a reactive oxygen species-generating compound, leads to the identification of long-lived mutants. Indeed, four of six resistant mutants isolated were also long-lived. This study illustrates once more the strong relationship between oxidative stress and the aging processes.
活性氧攻击造成的分子损伤积累是衰老的一个原因。因此，一些对活性氧具有更高抗性的突变生物体应该寿命更长。我们发现，选择对胡桃醌（一种能产生活性氧的化合物）具有抗性的秀丽隐杆线虫突变体，能够鉴定出长寿突变体。事实上，分离出的六个抗性突变体中有四个也是长寿的。这项研究再次说明了氧化应激与衰老过程之间的紧密关系。
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