Re M C, Zauli G, Furlini G, Vignoli M, Ramazzotti E, Ranieri S, La Placa M
Institute of Microbiology, University of Bologna, Italy.
AIDS Res Hum Retroviruses. 1992 Jul;8(7):1289-95. doi: 10.1089/aid.1992.8.1289.
In this study we evaluated interleukin-6 (IL-6) plasma levels in 80 human immunodeficiency virus type 1 (HIV-1) seropositive (+) individuals and 51 HIV-1 seronegative (-) blood donors. Plasma IL-6, detectable only in a subset of HIV-1(+) individuals (45 of 80) and normal blood donors (28 of 51), was significantly (p less than 0.01) increased in HIV-1(+) subjects 187 +/- 20.5 vs. 86.3 +/- 14 pg/ml). Among HIV-1-infected individuals, ARC/AIDS patients showed the highest IL-6 values (243.3 +/- 43.3 pg/ml). HIV-1(+) subjects showed, at all the different stages of the disease, a significant increase in total gammaglobulins, particularly IgG (2071 +/- 101 vs 1265 +/- 34 of HIV-1 seronegative controls). Although among HIV-1-infected individuals, the group with detectable plasma levels of IL-6 shows the highest levels of IgG (2243 +/- 146 vs. 1790 +/- 105, p less than 0.05), no positive correlations were observed between plasma levels of IL-6 and total gamma globulins (r = 0.2) or IgG (0.17). IL-6 production was also examined in the endotoxin-free supernatants of peripheral blood cultured monocytes and CD4+ T lymphocytes, in the presence or absence of specific stimuli. The amount of IL-6 released in monocyte and CD4+ T-lymphocyte culture supernatants was similar in 40 HIV-1(+) individuals and 35 HIV-1(-) controls. Our data show that plasma levels of IL-6 are significantly increased in HIV-1-infected individuals, in particular in ARC/AIDS patients. However, such an increase does not strictly correlate with the degree of hypergammaglobulinemia in the same HIV-1-infected individuals.
在本研究中，我们评估了80例1型人类免疫缺陷病毒（HIV-1）血清阳性（+）个体和51例HIV-1血清阴性（-）献血者的血浆白细胞介素-6（IL-6）水平。血浆IL-6仅在一部分HIV-1（+）个体（80例中的45例）和正常献血者（51例中的28例）中可检测到，HIV-1（+）受试者的血浆IL-6水平显著升高（p<0.01）（187±20.5 vs. 86.3±14 pg/ml）。在HIV-1感染个体中，艾滋病相关综合征/艾滋病（ARC/AIDS）患者的IL-6值最高（243.3±43.3 pg/ml）。在疾病的所有不同阶段，HIV-1（+）受试者的总丙种球蛋白，尤其是IgG显著增加（2071±101 vs. HIV-1血清阴性对照的1265±34）。尽管在HIV-1感染个体中，血浆IL-6水平可检测到的组显示出最高的IgG水平（2243±146 vs. 1790±105，p<0.05），但未观察到血浆IL-6水平与总丙种球蛋白（r = 0.2）或IgG（0.17）之间存在正相关。在有或无特定刺激的情况下，还对外周血培养的单核细胞和CD4+ T淋巴细胞的无内毒素上清液中的IL-6产生进行了检测。40例HIV-1（+）个体和35例HIV-1（-）对照的单核细胞和CD4+ T淋巴细胞培养上清液中释放的IL-6量相似。我们的数据表明，HIV-1感染个体，尤其是ARC/AIDS患者的血浆IL-6水平显著升高。然而，这种升高与同一HIV-1感染个体的高丙种球蛋白血症程度并不严格相关。
