CD25+调节性T细胞和预激活的CD25+调节性T细胞对Th2细胞发育、功能激活及增殖的差异调节能力。

Differential regulatory capacity of CD25+ T regulatory cells and preactivated CD25+ T regulatory cells on development, functional activation, and proliferation of Th2 cells.

作者信息

Stassen Michael, Jonuleit Helmut, Müller Christian, Klein Matthias, Richter Christoph, Bopp Tobias, Schmitt Steffen, Schmitt Edgar

机构信息

Institute of Immunology, Johannes Gutenberg University, Hochhaus am Augustusplatz, D-55101 Mainz, Germany.

出版信息

J Immunol. 2004 Jul 1;173(1):267-74. doi: 10.4049/jimmunol.173.1.267.

DOI:10.4049/jimmunol.173.1.267

Abstract

CD25+ T regulatory (Treg) cells play a central role regarding the maintenance of peripheral tolerance via suppression of autoaggressive CD4+ T cells, CD8+ T cells, and Th1 cells. In this study we demonstrate that CD25+ Treg cells can also suppress the differentiation of murine conventional CD4+ T cells toward Th2 cells in a contact-dependent manner. However, the cytokine production and proliferation of established Th2 cells could not be inhibited by freshly isolated CD25+ Treg cells, whereas a strong inhibition of differentiated Th2 cells by in vitro preactivated CD25+ Treg cells could be observed. Inhibition of both conventional CD4+ T cells and Th2 cells is accompanied by a strong enhancement of the expression of FoxP3 in the suppressed T cells. Hence, our study indicates that CD25+ Treg cells have a therapeutic potential for Th2-mediated diseases and suggests a novel mechanism of suppression mediated by the transcriptional repressor FoxP3.

摘要

CD25 + 调节性T（Treg）细胞通过抑制自身攻击性CD4 + T细胞、CD8 + T细胞和Th1细胞，在维持外周免疫耐受方面发挥核心作用。在本研究中，我们证明CD25 + Treg细胞也能以接触依赖的方式抑制小鼠传统CD4 + T细胞向Th2细胞的分化。然而，新鲜分离的CD25 + Treg细胞不能抑制已建立的Th2细胞的细胞因子产生和增殖，而体外预激活的CD25 + Treg细胞对分化的Th2细胞有强烈的抑制作用。对传统CD4 + T细胞和Th2细胞的抑制都伴随着被抑制的T细胞中FoxP3表达的强烈增强。因此，我们的研究表明CD25 + Treg细胞对Th2介导的疾病具有治疗潜力，并提示了由转录抑制因子FoxP3介导的一种新的抑制机制。