Cavaletti G, Beronio A, Reni L, Ghiglione E, Schenone A, Briani C, Zara G, Cocito D, Isoardo G, Ciaramitaro P, Plasmati R, Pastorelli F, Frigo M, Piatti M, Carpo M
Dipartimento di Neuroscienze e Tecnologie Biomediche, Università di Milano Bicocca, Monza, Italia.
Neurology. 2004 Jun 22;62(12):2291-3. doi: 10.1212/wnl.62.12.2291.
The clinical and neurophysiologic data from 65 patients taking thalidomide were reviewed. Thalidomide sensory neurotoxicity was found to be cumulative dose dependent but occurs only when the total dose is relatively high (>20 g). The risk of developing sensory neuropathy is around 10% below this threshold but increases with higher doses.
对65例服用沙利度胺的患者的临床和神经生理学数据进行了回顾。发现沙利度胺感觉神经毒性具有累积剂量依赖性，但仅在总剂量相对较高（>20 g）时才会发生。低于此阈值时发生感觉神经病变的风险约为10%，但随着剂量增加而升高。
