原发性震颤患者对辛酸的中枢和外周震颤成分的反应。
The response of the central and peripheral tremor component to octanoic acid in patients with essential tremor.
机构信息
Department of Neurology, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University, 277 Yanta Western Road, Xi'an 710061, China; National Institute of Neurological Disorders and Stroke, National Institutes of Health, 9000 Rockville Pike, Building 10, Bethesda, MD 20892, USA.
National Institute of Neurological Disorders and Stroke, National Institutes of Health, 9000 Rockville Pike, Building 10, Bethesda, MD 20892, USA.
出版信息
Clin Neurophysiol. 2018 Jul;129(7):1467-1471. doi: 10.1016/j.clinph.2018.03.016. Epub 2018 Apr 3.
OBJECTIVE
To investigate the effect of octanoic acid (OA) on the peripheral component of tremor, as well as OA's differential effects on the central and peripheral tremor component in essential tremor (ET) patients.
METHODS
We analyzed postural tremor accelerometry data from a double-blind placebo-controlled cross-over study evaluating the effect of 4 mg/kg OA in ET. The weighted condition was used to identify tremor power for both the central and peripheral tremor components. Exploratory non-parametric statistical analyses were used to describe the relation between the central and peripheral component of tremor power.
RESULTS
A peripheral tremor component was identified in 4 out of 18 subjects. Tremor power was reduced after OA administration in both the central and the peripheral tremor component. There was a positive correlation of tremor power between the central and peripheral component, both after placebo and OA.
CONCLUSIONS
When present, the peripheral component was closely related to the central tremor component. We hypothesize that the magnitude of the peripheral mechanical component of tremor is determined by that of the central component.
SIGNIFICANCE
Both central and peripheral component of tremor are reduced after OA, with the central component providing the energy driving the peripheral component.
目的
研究辛酸（OA）对震颤外周成分的影响，以及 OA 对特发性震颤（ET）患者中枢和外周震颤成分的差异影响。
方法
我们分析了一项双盲安慰剂对照交叉研究中姿势震颤加速计数据，该研究评估了 4mg/kgOA 对 ET 的影响。使用加权条件来识别中枢和外周震颤功率的震颤功率。探索性非参数统计分析用于描述震颤功率的中枢和外周成分之间的关系。
结果
18 名受试者中有 4 名确定存在外周震颤成分。OA 给药后，中枢和外周震颤成分的震颤功率均降低。在安慰剂和 OA 后，中枢和外周震颤成分之间均存在震颤功率的正相关关系。
结论
当存在时，外周成分与中枢震颤成分密切相关。我们假设震颤的外周机械成分的幅度由中枢成分决定。
意义
OA 后中枢和外周震颤成分均降低，其中中枢成分提供驱动外周成分的能量。
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