Jones Franca R, Sanchez Jose L, Meza Rina, Batsel Tanis M, Burga Rosa, Canal Enrique, Block Karla, Perez Juan, Bautista Christian T, Escobedo Jorge, Walz Stephen E
U.S. Naval Medical Research Center Detachment, American Embassy, Lima, Peru.
Am J Trop Med Hyg. 2004 Jun;70(6):663-5.
We investigated the etiology of acute diarrhea among Peruvian military recruits undergoing three months of basic combat training near the Amazonian city of Iquitos. From January through September 2002, 307 of 967 recruits were seen at the Health Post for diarrhea (attack rate [AR] = 31.8%, incidence = 1.28 95% confidence interval [CI] = 1.14-1.43] episodes/person-year). Shigella spp. were the most common bacterial pathogen recovered from recruits experiencing diarrhea episodes. These bacteria were isolated from 89 (40%) of 225 diarrheal stools examined (AR = 7.6%, incidence = 0.30 [95% CI = 0.24-0.38] episodes/person-year). Most (83 of 90; 92%) of the Shigella isolates were S. flexneri, of which 57 (69%) were serotype 2a. Seventy-six percent of Shigella isolates were resistant to sulfamethoxazole/trimethoprim and all were sensitive to ciprofloxacin. Peruvian soldiers may be an excellent population in which to test the efficacy of S. flexneri vaccines in advanced development.
我们调查了在亚马逊城市伊基托斯附近接受为期三个月基础战斗训练的秘鲁新兵中急性腹泻的病因。2002年1月至9月期间,967名新兵中有307人因腹泻前往卫生站就诊(发病率[AR]=31.8%,发病率=1.28[95%置信区间(CI)=1.14 - 1.43]次/人年)。志贺氏菌属是从腹泻新兵中分离出的最常见细菌病原体。在225份腹泻粪便样本中,有89份(40%)检出这些细菌(AR = 7.6%,发病率 = 0.30[95% CI = 0.24 - 0.38]次/人年)。大多数(90份中的83份;92%)志贺氏菌分离株为福氏志贺菌,其中57份(69%)为2a血清型。76%的志贺氏菌分离株对磺胺甲恶唑/甲氧苄啶耐药,对环丙沙星均敏感。秘鲁士兵可能是测试处于后期研发阶段的福氏志贺菌疫苗疗效的理想人群。