Maachi M, Piéroni L, Bruckert E, Jardel C, Fellahi S, Hainque B, Capeau J, Bastard J-P
Service de Biochimie et Hormonologie, Hôpital Tenon, AP-HP, France.
Int J Obes Relat Metab Disord. 2004 Aug;28(8):993-7. doi: 10.1038/sj.ijo.0802718.
We assessed the relationships between four circulating acute phase proteins and the circulating and adipose tissue levels of three adipocytokines.
In all, 15 nondiabetic obese women with a body mass index (BMI) above 32 kg/m(2) were investigated.
Circulating concentrations of C-reactive protein (CRP), alpha 1 acid glycoprotein (AAG), fibrinogen, alpha 1 antitrypsin and both circulating and adipose tissue levels of interleukin (IL)-6, tumor necrosis factor (TNF)alpha and leptin were measured by either nephelometry or enzyme-linked immunosorbent assay.
We found a strong positive correlation between both circulating and adipose tissue levels of IL-6, TNFalpha and leptin and serum CRP levels. All these adipose tissue adipocytokines were also positively correlated with serum AAG levels. These correlations disappeared when adjusted for fat mass, suggesting that the relationship observed was dependent on fat amount.
Our results indicate a strong relationship between adipocytokines and inflammatory markers, and suggest that cytokines secreted by adipose tissue in obese subjects could play a role in increased inflammatory proteins secretion by the liver.
我们评估了四种循环急性期蛋白与三种脂肪细胞因子的循环及脂肪组织水平之间的关系。
总共对15名体重指数（BMI）高于32 kg/m²的非糖尿病肥胖女性进行了研究。
采用散射比浊法或酶联免疫吸附测定法测量C反应蛋白（CRP）、α1酸性糖蛋白（AAG）、纤维蛋白原、α1抗胰蛋白酶的循环浓度，以及白细胞介素（IL）-6、肿瘤坏死因子（TNF）α和瘦素的循环及脂肪组织水平。
我们发现IL-6、TNFα和瘦素的循环及脂肪组织水平与血清CRP水平之间存在强正相关。所有这些脂肪组织脂肪细胞因子也与血清AAG水平呈正相关。在对脂肪量进行校正后，这些相关性消失，表明观察到的关系取决于脂肪量。
我们的数据表明脂肪细胞因子与炎症标志物之间存在密切关系，并提示肥胖受试者脂肪组织分泌的细胞因子可能在肝脏炎症蛋白分泌增加中起作用。
