Altieri Dario C
Department of Cancer Biology and the Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01609, USA.
J Cell Biochem. 2004 Jul 1;92(4):656-63. doi: 10.1002/jcb.20140.
The coupling of cell proliferation to cell death is thought to function as a pivotal crossroad, essential to preserve normal homeostasis and to eliminate dangerous cells before they divide. Survivin is a prototype molecule at this crossroad, intercalated in protection against mitochondrial cell death and orchestrating various aspects of cell division. Dramatically exploited in cancer and an unfavorable gene signature for disease outcome, the survivin pathway has now provided tangible opportunities for targeted, rational cancer therapy.
细胞增殖与细胞死亡的耦合被认为是一个关键的十字路口，对于维持正常的内环境稳定以及在危险细胞分裂之前将其清除至关重要。生存素是这个十字路口的一个典型分子，它参与保护细胞免受线粒体细胞死亡的影响，并协调细胞分裂的各个方面。生存素途径在癌症中被大量利用，并且是疾病预后的不良基因特征，现在它为靶向、合理的癌症治疗提供了切实的机会。
