Bardi G, Johansson B, Pandis N, Heim S, Mandahl N, Bak-Jensen E, Frederiksen H, Andrén-Sandberg A, Mitelman F
Department of Clinical Genetics, Lund University Hospital, Sweden.
Cancer Genet Cytogenet. 1992 Aug;62(1):43-6. doi: 10.1016/0165-4608(92)90036-8.
Short-term cultures of four abdominal smooth muscle tumors, three leiomyosarcomas and one leiomyoma, were analyzed cytogenetically. A low-grade malignant, epithelioid leiomyosarcoma had a normal karyotype. The other two leiomyosarcomas had abnormal karyotypes; one was near-diploid, and the other was near-triploid. Structural rearrangements of the short arm of chromosome 16 and monosomies of chromosomes 14, 15, and 22 were observed in both tumors. When our cases and previously published abdominal leiomyosarcomas are viewed in conjunction, loss of chromosomes 14, 15, and 22 are the most frequent abnormalities. The leiomyoma, the second cytogenetically abnormal nonuterine leiomyoma reported to date, had a hyperdiploid karyotype with a chromosome number of 56 and structural rearrangements of chromosomes 9, 14, and 19. The only aberrations similar to those observed in the previously reported esophageal leiomyoma were trisomies of chromosomes 7 and 8.
对4例腹部平滑肌肿瘤（3例平滑肌肉瘤和1例平滑肌瘤）进行了短期培养，并进行了细胞遗传学分析。1例低级别恶性上皮样平滑肌肉瘤核型正常。另外2例平滑肌肉瘤核型异常；1例接近二倍体，另1例接近三倍体。在这2例肿瘤中均观察到16号染色体短臂的结构重排以及14、15和22号染色体的单体性。将我们的病例与先前发表的腹部平滑肌肉瘤一起分析时，14、15和22号染色体缺失是最常见的异常情况。该平滑肌瘤是迄今为止报道的第二例细胞遗传学异常的非子宫平滑肌瘤，其核型为超二倍体，染色体数为56，9、14和19号染色体存在结构重排。与先前报道的食管平滑肌瘤中观察到的唯一相似异常是7号和8号染色体三体性。
