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分泌因子基因Fut2缺失小鼠对实验性阴道念珠菌病的易感性增加。

Increased susceptibility of secretor factor gene Fut2-null mice to experimental vaginal candidiasis.

作者信息

Hurd Elizabeth A, Domino Steven E

机构信息

Department of Obstetrics and Gynecology, 6428 Medical Science I, Box 0617, University of Michigan, Ann Arbor, MI 48109-0617, USA.

出版信息

Infect Immun. 2004 Jul;72(7):4279-81. doi: 10.1128/IAI.72.7.4279-4281.2004.

DOI:10.1128/IAI.72.7.4279-4281.2004
PMID:15213174
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC427463/
Abstract

Fut2-LacZ-null mice, which are a model of the human ABO and Lewis nonsecretor group, display increased susceptibility to experimental yeast vaginitis, indicating a role for alpha(1,2)fucosylated cervical glycans in mucosal defense. However, the lack of significant effect of competitive inhibition by exogenous neoglycoproteins in this study emphasizes the complexity of Candida-epithelial cell adhesion events.

摘要

Fut2-LacZ基因敲除小鼠是人类ABO和Lewis非分泌型血型的模型，对实验性酵母性阴道炎的易感性增加，表明α(1,2)岩藻糖基化宫颈聚糖在黏膜防御中发挥作用。然而，本研究中外源新糖蛋白竞争性抑制作用缺乏显著效果，这突出了念珠菌与上皮细胞黏附事件的复杂性。

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本文引用的文献

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Evolution of human calicivirus RNA in vivo: accumulation of mutations in the protruding P2 domain of the capsid leads to structural changes and possibly a new phenotype.人杯状病毒RNA在体内的进化：衣壳突出P2结构域中突变的积累导致结构变化并可能产生新的表型。
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LacZ expression in Fut2-LacZ reporter mice reveals estrogen-regulated endocervical glandular expression during estrous cycle, hormone replacement, and pregnancy.Fut2-LacZ报告基因小鼠中的LacZ表达揭示了发情周期、激素替代和妊娠期间雌激素调节的宫颈腺表达。
Glycobiology. 2004 Feb;14(2):169-75. doi: 10.1093/glycob/cwh019. Epub 2003 Oct 23.
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Campylobacter jejuni binds intestinal H(O) antigen (Fuc alpha 1, 2Gal beta 1, 4GlcNAc), and fucosyloligosaccharides of human milk inhibit its binding and infection.空肠弯曲菌可结合肠道H(O)抗原（岩藻糖α1,2-半乳糖β1,4-N-乙酰葡糖胺），而人乳中的岩藻糖基低聚糖可抑制其结合及感染。
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Immunity to Candida.对念珠菌的免疫力
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Deficiency of reproductive tract alpha(1,2)fucosylated glycans and normal fertility in mice with targeted deletions of the FUT1 or FUT2 alpha(1,2)fucosyltransferase locus.FUT1或FUT2α（1,2）岩藻糖基转移酶基因座靶向缺失小鼠的生殖道α（1,2）岩藻糖基化聚糖缺乏与正常生育能力
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Growth inhibition of Candida albicans by human vaginal epithelial cells.人阴道上皮细胞对白色念珠菌的生长抑制作用
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Contrasting patterns of polymorphisms at the ABO-secretor gene (FUT2) and plasma alpha(1,3)fucosyltransferase gene (FUT6) in human populations.人类群体中ABO分泌型基因（FUT2）和血浆α（1,3）岩藻糖基转移酶基因（FUT6）多态性的对比模式。
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