Vanhanen H T, Miettinen T A
Second Department of Medicine, University of Helsinki, Finland.
Clin Chim Acta. 1992 Jan 31;205(1-2):97-107. doi: 10.1016/s0009-8981(05)80004-x.
Rapeseed oil fed to 24 hypercholesterolemic patients (50 g/day) reduced serum cholesterol (-8.5%) and cholestanol concentrations but increased those of campesterol and sitosterol. Continuation of rapeseed oil alone or with added sitosterol (625 mg/day) or sitostanol (630 mg/day) had no further effect on serum cholesterol. Rapeseed oil with sitosterol increased further its own proportion to cholesterol in serum but reduced that of campesterol while rapeseed oil with sitostanol reduced the proportions of both sitosterol and campesterol proportionately to the pretreatment values. The changes in the campesterol and sitosterol proportions were negatively and positively related to each other during the sitosterol and sitostanol additions, respectively. Thus, concentrations of unsaturated plant sterols in serum reflect their dietary intakes, saturated plant sterols are virtually not absorbed, plant sterols interfere with absorption of unsaturated structurally different plant sterols and cholestanol, and plant sterol-induced reduction of sterol absorption may be positively related to absorption efficiency of sterols.
给24名高胆固醇血症患者喂食菜籽油（50克/天）可降低血清胆固醇（-8.5%）和胆甾烷醇浓度，但会增加菜油甾醇和谷甾醇的浓度。单独持续喂食菜籽油或添加谷甾醇（625毫克/天）或谷甾烷醇（630毫克/天）对血清胆固醇没有进一步影响。添加谷甾醇的菜籽油进一步增加了其在血清中与胆固醇的比例，但降低了菜油甾醇的比例，而添加谷甾烷醇的菜籽油则使谷甾醇和菜油甾醇的比例相对于预处理值成比例降低。在添加谷甾醇和谷甾烷醇的过程中，菜油甾醇和谷甾醇比例的变化分别呈负相关和正相关。因此，血清中不饱和植物甾醇的浓度反映了它们的膳食摄入量，饱和植物甾醇几乎不被吸收，植物甾醇会干扰结构不同的不饱和植物甾醇和胆甾烷醇的吸收，并且植物甾醇引起的甾醇吸收减少可能与甾醇的吸收效率呈正相关。
