恶性高热中的普鲁卡因。
Procaine in malignant hyperpyrexia.
作者信息
Moulds R F, Denborough M A
出版信息
Br Med J. 1972 Dec 2;4(5839):526-8. doi: 10.1136/bmj.4.5839.526.
Abstract
The caffeine contracture of normal human muscle, which has been used as a model for malignant hyperpyrexia, is greatly potentiated by halothane. Prior administration of procaine markedly reduces the halothane-potentiated caffeine contracture, and procaine given at the height of the contracture induces relaxation. Lignocaine, on the other hand, produces a variable response and sometimes increases the contracture.The muscle from a patient with an inherited susceptibility to malignant hyperpyrexia contracted spontaneously with halothane alone, and this contracture was reversed by procaine.These experiments support the therapeutic use of procaine in malignant hyperpyrexia.
摘要
正常人体肌肉的咖啡因挛缩已被用作恶性高热的模型，氟烷可极大地增强这种挛缩。预先给予普鲁卡因可显著降低氟烷增强的咖啡因挛缩，且在挛缩高峰时给予普鲁卡因可诱导松弛。另一方面，利多卡因产生的反应不一，有时会增加挛缩。患有遗传性恶性高热易感性的患者的肌肉仅与氟烷就会自发收缩，而这种挛缩可被普鲁卡因逆转。这些实验支持了普鲁卡因在恶性高热治疗中的应用。
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本文引用的文献
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